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Shinbiosis Corporation

Company Name: Shinbiosis Corporation
Head Office Address: 401 Est Nouveau, 2-1-40, Katamachi, Miyakojima-ku, Osaka-shi, Osaka 534-0025, Japan
Laboratory Plant: Room 103, Kobe Health Industry Center, 6-7-4 Minatojima-Minamimachi, Chuo-ku,
Kobe, Hyogo 650-0047, Japan
Date of Establishment: Dec. 4, 2017
Representative Director: Mikiko Tanaka
capital stock: 20 million yen

Affiliated Companies and Organizations

Intestinal Flora Transplant Clinical Research Foundation

Corporate Name: The Association for Clinical Research of Fecal Microbiota Transplantation Japan
address (e.g. of house): 401 Est Nouveau, 2-1-40, Katamachi, Miyakojima-ku, Osaka-shi, Osaka 534-0025, Japan
Date of Establishment: Nov. 19, 2017
officer: Representative Director: Yoshiyoshi Tanaka
and 1 other Executive Director 4 Directors 3 Councilors
1 Auditor 1 Academic Advisor
1 Chief Advisor 2 Technical Advisors

Intestinal Flora Transplant Clinical Research, Inc.

Company Name: Clinical Research of Fecal Microbiota Transplantation Japan Corporation
address (e.g. of house): 401 Est Nouveau, 2-1-40, Katamachi, Miyakojima-ku, Osaka-shi, Osaka 534-0025, Japan
Date of Establishment: Oct. 20, 2017
Representative Director: Mikiko Tanaka
Relationship with Shinbiosis Corporation: The Intestinal Flora Transplantation Clinical Research Group, a general incorporated
foundation, is led by clinicians and is working to establish a new treatment called
"Fecal Microflora Transplantation (FMT)".
Our company is responsible for the research and development of NanoGAS® water
as a transplantation solution and solvent for fecal microflora transplantation (FMT),
and provides the solution to medical institutions belonging to the research group.
Intestinal Flora Transplantation Clinical Research, Inc. serves as the secretariat of the
research group.

History

Nov. 2023

Received the Small and Medium Enterprise Agency Director-General's Award for the patent for "FMT using nanobubbles.
Nov. 2023

Selected for a grant from the New Energy and Industrial Technology Development Organization (NEDO), a national research and development corporation
Sep. 2023

The 7th Annual Meeting of the Society for Clinical Research on Intestinal Flora Transplantation held.
Ap. 2023

Clinical research begins on autism spectrum disorder.
Oct. 2022

Joint research paper with Kobe Gakuin University Faculty of Nutrition accepted in May and
published in Biocontrol Science

Morishita R, Itoh S, Takeda-Morishita M. Evaluation of Bactericidal Effects of H2- and 03-filled
Ultrafine Bubbles Water. Biocontrol Sci. 2022;27(3):139-142.
Sep. 2022

The 6th Annual Meeting of the Society for Clinical Research on Intestinal Flora
Transplantation held.
Aug. 2022

Application of Nanobubble Water for DDS Patent Published
Aug. 2022

Investment by the "Osaka Social Problem Solving Fund No. 2" was executed.

[Social issue to be solved: Establishment of a new medical treatment for autistic spectrum
disorder, ulcerative colitis, renal disease, etc., for which no treatment methods have been
established, using "intestinal flora transplantation".
Jul. 2022

Application of Nanobubble Water for DDS Patent Published
Jun. 2022

Presented the results of joint research with the Faculty of Pharmacy at the 38th Annual Meeting of the Japanese DDS Society "Society's Disadvantages and DDS"

Transdermal, Transpulmonary, and Transmucosal Delivery
Evaluation of NanoGAS® (NanoBubble) Water for Oral Insulin Absorption Enhancement
Jun. 2022

International patent application filed (Taiwan) for automatic purification system for bacterial
solution
May. 2022

Received the Nagai Foundation Undergraduate Student Seven-Star Pharmacy Incentive
Award for collaborative research results at the 37th Annual Meeting of the Japanese
Pharmaceutical Association held online.

Presentation Title
Effect of NanoGAS® (Nanobubble) water on transmucosal absorption of insulin
May. 2022

Patent registered for nanobubble production device (rotating mixer)
May. 2022

Joint research paper with Faculty of Nutrition, Kobe Gakuin University accepted for
publication in Biocontrol Science

Title of paper: Evaluation of Bactericidal Effects of H2- and 03-filled Ultrafine Bubbles Water
Authors: Risako Morishita, Satoshi Ito and Mariko Takeda-Morishita
Feb. 2022

Patent registered for nanobubble production device (bubble shear filter)
Feb. 2022

Received the Chairman's Award (Grand Prize) at the 3rd Osaka Shinkin Bank's
"Entrepreneurial Business Plan Contest".

Content of Presentation
Revolutionizing medicine and industry with the technology of fine bubbles that will not
disappear even after 10 years!
Dec. 2021

International patent application filed (U.S.A., Europe, China, Korea) for nanobubble
production equipment (rotating mixer)
Sep. 2021

The 5th Annual Meeting of the Intestinal Flora Transplantation Clinical Research Foundation
held
Sep. 2021

Yoshimu Tanaka, President of our study group (President of Tanaka Clinic, Jinzenkai Medical
Corporation), published an article in "Nutrients

Nutrition and Cancer Risk from the Viewpoint of the Intestinal Microbiome by
Yoshimu Tanaka, Shin Shimizu, Masahiko Shirotani, Kensho Yorozu, Kunihiro Kitamura,
Masayuki Oeholm, Yuichi Kawai and Yoshitaka Fukuzawa
The usefulness of NanoGAS®-FMT (NanoGAS®-FMT), a gut flora transplant using NanoGAS® water, as a method to optimize intestinal bacteria to reduce the risk of cancer, is also
introduced.
Sep. 2021

Hyogo Cutting-edge Technology Project COE Program, Application Stage Research
"Research on the Application and Practical Use of NanoGAS ® NanoGASTM in the
Medical Field" was adopted as a new project.
Aug. 2021

Subsidy for Promotion of Productivity Improvement in Manufacturing, Commerce, and
Services Supplemented in FY2049 Grant Decision

To respond to the growing market for intestinal flora transplantation, a new plant will be
installed and an automatic adjustment system for bacterial solution will be developed.
Aug. 2021

Application of Nanobubble Water for DDS International Patent Applications
(U.S., EUROPE, CHINA, KOREA)
Jun. 2021

Presented the results of joint research with the Faculty of Pharmacy
and Pharmaceutical Sciences at the 37th annual meeting of the Japanese DDS Society
"Science and Technology Pioneer DDS

Abstracts
Biomolecular Delivery
Evaluation of drinking safety and physiological effects of NanoGAS®(Nanobubble) water
(Poster) Transdermal, Transpulmonary and Transmucosal Delivery Biomolecular Delivery
Effect of NanoGAS®(Nanobubble) Water on Gastrointestinal Absorption of
Biopharmaceuticals (Oral Presentation)
Jun. 2021

Grant decision for business restructuring subsidy

Relocate manufacturing facilities for NanoGAS® water and enhance manufacturing capacity
and R&D capabilities for existing and new ozone NanoGAS® water
Jun. 2021

Joint patent application with Kobe Gakuin University
Jun. 2021

Patent application for a bacterial solution production system
Mar. 2021

International Patent Application for Nanobubble Manufacturing Equipment
(Bubble Shear Filter) (Taiwan)
Mar. 2021

Patent divisional application for nanobubble production device (rotating mixer)
Mar. 2021

Proprietary Logic for Evaluation of Intestinal Flora Balance Patent Disclosure
Feb. 2021

Laboratory and plant are expanded in Port Island, Kobe for business expansion.
Dec. 2020

Named the proprietary platform technology NanoGAS®.
Oct. 2020

With the expansion of business scale, reorganized Symbiosis LLC to Symbiosis Inc.
and increased the capital to 10 million yen.
Aug. 2020

Paper submitted to
"Usefulness of NanoGAS ®(UFB) water in intestinal flora transplantation
~recognition of transplanted bacteria in intestinal epithelial cells"
Sep. 2020

The 4th Annual Meeting of the Intestinal Flora Transplantation Clinical Research Foundation
held.
Aug. 2020

Exhibited at the 36th Annual Meeting of the Japanese DDS Society "DDS Creates
Future Medical Modalities
Aug. 2020

Signed a joint research agreement with the Faculty of Nutrition, Kobe Gakuin University,
and began joint research.
May. 2020

Patent application for virus removal
May. 2020

Signed a joint research agreement with Kobe Gakuin University and started joint research.
May. 2020

Patent application filed for a new method of utilizing high-performance nanobubble
technology.
Mar. 2020

Nanobubble Manufacturing Device Patent Applied for
Sep. 2019

The 3rd Annual Meeting of the Intestinal Flora Transplantation Clinical Research Foundation
held.
Sep. 2019

Patent application filed for a formula that summarizes the findings of intestinal flora analysis
to date.
Sep. 2019

Filed international patent applications (U.S., Europe, China, and South Korea) for a method of producing bacterial solution using high-performance nanobubble water.
Aug. 2019

Patent application with expanded scope of rights for wider use of high-performance
nanobubble technology
Feb. 2019

Production method of bacterial solution using highly functional nanobubble water Patent application
Feb. 2019

Application of Nanobubble Water for DDS International Patent Application
Oct. 2018

The 2nd General Meeting of the Intestinal Flora Transplantation Clinical Research Foundation held.
Feb. 2018

Patent application for transplantation bacteria solution using high-performance nanobubble
technology
Dec. 2017

Shinbiosis LLC is established.
Nov.2017

Establishment of the Intestinal Flora Transplantation Clinical Research Foundation and
the first general meeting is held.
Oct. 2017

Establishment of Intestinal Flora Transplant Clinical Research Co.

Established in preparation for the establishment of a research group to serve as
the secretariat of the Intestinal Flora Transplantation Clinical Research Group,
a general incorporated foundation.

Access (Kobe Lab)

Postal Code 650-0047
6-7-4 Minatojima Minami-cho, Chuo-ku, Kobe-shi, Hyogo
Kobe Health Industry Development Center Room 103
Symbiosis Corporation (Symbiosis Research Institute)