History

1. Nov. 2023

   Received the Small and Medium Enterprise Agency Director-General's Award for the patent for "FMT using nanobubbles.

2. Nov. 2023

   Selected for a grant from the New Energy and Industrial Technology Development Organization (NEDO), a national research and development corporation

3. Sep. 2023

   The 7th Annual Meeting of the Society for Clinical Research on Intestinal Flora Transplantation held.

4. Ap. 2023

   Clinical research begins on autism spectrum disorder.

5. Oct. 2022

   Joint research paper with Kobe Gakuin University Faculty of Nutrition accepted in May and
   published in Biocontrol Science

   Morishita R, Itoh S, Takeda-Morishita M. Evaluation of Bactericidal Effects of H2- and 03-filled
   Ultrafine Bubbles Water. Biocontrol Sci. 2022;27(3):139-142.

6. Sep. 2022

   The 6th Annual Meeting of the Society for Clinical Research on Intestinal Flora
   Transplantation held.

7. Aug. 2022

   Application of Nanobubble Water for DDS Patent Published

8. Aug. 2022

   Investment by the "Osaka Social Problem Solving Fund No. 2" was executed.

   [Social issue to be solved: Establishment of a new medical treatment for autistic spectrum
   disorder, ulcerative colitis, renal disease, etc., for which no treatment methods have been
   established, using "intestinal flora transplantation".

9. Jul. 2022

   Application of Nanobubble Water for DDS Patent Published

10. Jun. 2022

    Presented the results of joint research with the Faculty of Pharmacy at the 38th Annual Meeting of the Japanese DDS Society "Society's Disadvantages and DDS"

    Transdermal, Transpulmonary, and Transmucosal Delivery
    Evaluation of NanoGAS® (NanoBubble) Water for Oral Insulin Absorption Enhancement

11. Jun. 2022

    International patent application filed (Taiwan) for automatic purification system for bacterial
    solution

12. May. 2022

    Received the Nagai Foundation Undergraduate Student Seven-Star Pharmacy Incentive
    Award for collaborative research results at the 37th Annual Meeting of the Japanese
    Pharmaceutical Association held online.

    Presentation Title
    Effect of NanoGAS® (Nanobubble) water on transmucosal absorption of insulin

13. May. 2022

    Patent registered for nanobubble production device (rotating mixer)

14. May. 2022

    Joint research paper with Faculty of Nutrition, Kobe Gakuin University accepted for
    publication in Biocontrol Science

    Title of paper: Evaluation of Bactericidal Effects of H2- and 03-filled Ultrafine Bubbles Water
    Authors: Risako Morishita, Satoshi Ito and Mariko Takeda-Morishita

15. Feb. 2022

    Patent registered for nanobubble production device (bubble shear filter)

16. Feb. 2022

    Received the Chairman's Award (Grand Prize) at the 3rd Osaka Shinkin Bank's
    "Entrepreneurial Business Plan Contest".

    Content of Presentation
    Revolutionizing medicine and industry with the technology of fine bubbles that will not
    disappear even after 10 years!

17. Dec. 2021

    International patent application filed (U.S.A., Europe, China, Korea) for nanobubble
    production equipment (rotating mixer)

18. Sep. 2021

    The 5th Annual Meeting of the Intestinal Flora Transplantation Clinical Research Foundation
    held

19. Sep. 2021

    Yoshimu Tanaka, President of our study group (President of Tanaka Clinic, Jinzenkai Medical
    Corporation), published an article in "Nutrients

    Nutrition and Cancer Risk from the Viewpoint of the Intestinal Microbiome by
    Yoshimu Tanaka, Shin Shimizu, Masahiko Shirotani, Kensho Yorozu, Kunihiro Kitamura,
    Masayuki Oeholm, Yuichi Kawai and Yoshitaka Fukuzawa
    The usefulness of NanoGAS®-FMT (NanoGAS®-FMT), a gut flora transplant using NanoGAS® water, as a method to optimize intestinal bacteria to reduce the risk of cancer, is also
    introduced.

20. Sep. 2021

    Hyogo Cutting-edge Technology Project COE Program, Application Stage Research
    "Research on the Application and Practical Use of NanoGAS ® NanoGASTM in the
    Medical Field" was adopted as a new project.

21. Aug. 2021

    Subsidy for Promotion of Productivity Improvement in Manufacturing, Commerce, and
    Services Supplemented in FY2049 Grant Decision

    To respond to the growing market for intestinal flora transplantation, a new plant will be
    installed and an automatic adjustment system for bacterial solution will be developed.

22. Aug. 2021

    Application of Nanobubble Water for DDS International Patent Applications
    (U.S., EUROPE, CHINA, KOREA)

23. Jun. 2021

    Presented the results of joint research with the Faculty of Pharmacy
    and Pharmaceutical Sciences at the 37th annual meeting of the Japanese DDS Society
    "Science and Technology Pioneer DDS

    Abstracts
    Biomolecular Delivery
    Evaluation of drinking safety and physiological effects of NanoGAS®(Nanobubble) water
    (Poster) Transdermal, Transpulmonary and Transmucosal Delivery Biomolecular Delivery
    Effect of NanoGAS®(Nanobubble) Water on Gastrointestinal Absorption of
    Biopharmaceuticals (Oral Presentation)

24. Jun. 2021

    Grant decision for business restructuring subsidy

    Relocate manufacturing facilities for NanoGAS® water and enhance manufacturing capacity
    and R&D capabilities for existing and new ozone NanoGAS® water

25. Jun. 2021

    Joint patent application with Kobe Gakuin University

26. Jun. 2021

    Patent application for a bacterial solution production system

27. Mar. 2021

    International Patent Application for Nanobubble Manufacturing Equipment
    (Bubble Shear Filter) (Taiwan)

28. Mar. 2021

    Patent divisional application for nanobubble production device (rotating mixer)

29. Mar. 2021

    Proprietary Logic for Evaluation of Intestinal Flora Balance Patent Disclosure

30. Feb. 2021

    Laboratory and plant are expanded in Port Island, Kobe for business expansion.

31. Dec. 2020

    Named the proprietary platform technology NanoGAS®.

32. Oct. 2020

    With the expansion of business scale, reorganized Symbiosis LLC to Symbiosis Inc.
    and increased the capital to 10 million yen.

33. Aug. 2020

    Paper submitted to
    "Usefulness of NanoGAS ®(UFB) water in intestinal flora transplantation
    ~recognition of transplanted bacteria in intestinal epithelial cells"

34. Sep. 2020

    The 4th Annual Meeting of the Intestinal Flora Transplantation Clinical Research Foundation
    held.

35. Aug. 2020

    Exhibited at the 36th Annual Meeting of the Japanese DDS Society "DDS Creates
    Future Medical Modalities

36. Aug. 2020

    Signed a joint research agreement with the Faculty of Nutrition, Kobe Gakuin University,
    and began joint research.

37. May. 2020

    Patent application for virus removal

38. May. 2020

    Signed a joint research agreement with Kobe Gakuin University and started joint research.

39. May. 2020

    Patent application filed for a new method of utilizing high-performance nanobubble
    technology.

40. Mar. 2020

    Nanobubble Manufacturing Device Patent Applied for

41. Sep. 2019

    The 3rd Annual Meeting of the Intestinal Flora Transplantation Clinical Research Foundation
    held.

42. Sep. 2019

    Patent application filed for a formula that summarizes the findings of intestinal flora analysis
    to date.

43. Sep. 2019

    Filed international patent applications (U.S., Europe, China, and South Korea) for a method of producing bacterial solution using high-performance nanobubble water.

44. Aug. 2019

    Patent application with expanded scope of rights for wider use of high-performance
    nanobubble technology

45. Feb. 2019

    Production method of bacterial solution using highly functional nanobubble water Patent application

46. Feb. 2019

    Application of Nanobubble Water for DDS International Patent Application

47. Oct. 2018

    The 2nd General Meeting of the Intestinal Flora Transplantation Clinical Research Foundation held.

48. Feb. 2018

    Patent application for transplantation bacteria solution using high-performance nanobubble
    technology

49. Dec. 2017

    Shinbiosis LLC is established.

50. Nov.2017

    Establishment of the Intestinal Flora Transplantation Clinical Research Foundation and
    the first general meeting is held.

51. Oct. 2017

    Establishment of Intestinal Flora Transplant Clinical Research Co.

    Established in preparation for the establishment of a research group to serve as
    the secretariat of the Intestinal Flora Transplantation Clinical Research Group,
    a general incorporated foundation.